現任職務

醫療副院長
心臟內科主治醫師
部定助理教授

學經歷
中山醫學大學醫學分子毒理學研究所博士
國防醫學院醫學系
前國軍台中總醫院內科部主任
前國軍台中總醫院心臟內科主任
前國軍台中總醫院急診暨加護病房主任
前三軍總醫院心臟內科主治醫師 國際/國內(證照)
中華民國心臟學會專科醫師
心臟介入專科醫師
重症醫學專科醫師
內科專科醫師
心臟專科指導醫師
重症醫學專科指導醫師

主治項目
心臟超音波、心律調節器置放及心導管、冠狀動脈及週邊血管之介入性治療(氣球擴張術及支架放置)、各種心律不整之治療、心絞痛、心臟衰竭、心臟急重症、心肌梗塞、高血脂、瓣膜疾病、先天性心臟病、高血壓、胸悶、氣喘

其他卓越成就表現(例如得獎、榮譽、論文、著作)：
Histone acetylation is essential for ANG-II-induced IGF- IIR gene expression in H9c2 cardiomyoblast cells and pathologically hypertensive rat heart. Chu CH, Lo JF, Hu WS, Lu RB, Chang MH, Tsai FJ, Tsai CH, Weng YS, Tzang BS, Huang CY. J Cell Physiol. 2012 Jan;227(1):259-68. doi: 10.1002/jcp.22728.

Isolated septic discitis associated with Streptococcus bovis bacteremia. Yang DH, Chang MH, Chang WC. South Med J. 2011 May;104(5):375-7.

IGF-II and MMP9 as surgical repair indicators of ventricular septal defects. Tsai CY, Lai CH, Chang MH, Jong GP, Cheng YC, Tsai FJ, Tsai CH, Kuo WH, Hsieh DJ, Huang CY. Clin Chim Acta. 2011 Apr 11;412(9-10):761-5. Epub 2011 Jan 14.

Cardiac contractile dysfunction and apoptosis in streptozotocin-induced diabetic rats are ameliorated by garlic oil supplementation.

Ou HC, Tzang BS, Chang MH, Liu CT, Liu HW, Lii CK, Bau DT, Chao PM, Kuo WW. J Agric Food Chem. 2010 Oct 13;58(19):10347-55.

Proliferative effects of chishao on injured peripheral neurons. Fang WK, Weng YJ, Chang MH, Lin CC, Chen YS, Hsu HH, Tsai FJ, Tsai CH, Kuo WH, Lu CY, Huang CY. Am J Chin Med. 2010;38(4):735-43.

Rheumatoid factor is a strong risk factor for coronary artery disease in men with metabolic syndrome. Mu-Hsin Chang , Tsochiang Ma, Yi-Sheug Liou, Liyun Tien, En Hsuan Wu, Chao-Hung Lai and Gwo-Ping Jong Acta Cardiol Sin 2010;26:89-93.

Lipopolysaccharide upregulates uPA, MMP-2 and MMP-9 via ERK1/2 signaling in H9c2 cardiomyoblast cells. Cheng YC, Chen LM, Mu-Hsin Chang, Chen WK, Tsai FJ, Tsai CH, Lai TY, Kuo WW, Huang CY, Liu CJ. Mol Cell Biochem. 2009 May;325(1-2):15-23.

Antihypertensive drugs and new-onset diabetes: a retrospective longitudinal cohort study. Jong GP, Chang MH, Tien L, Li SY, Liou YS, Lung CH, Ma T. Cardiovasc Ther. 2009 Fall;27(3):159-63.

Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Galphaq signaling. Chen RJ, Wu HC, Chang MH, Tien YC, Hwang JM, Kuo WH, Tsai FJ, Tsai CH, Chen LM, Huang CY, Chu CH. J Mol Endocrinol. 2009 Dec;43(6):221-30. Epub 2009 Jun 25.

IGF-II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells. Mu-Hsin Chang, Wei-Wen Kuo, Ray-Jade Chen, Ming-Chin Lu, Fuu-Jen Tsai, Wu-Hsien Kuo, Ling-Yun Chen, Wen-Jun Wu, Chih-Yang Huang and Chun-Hsien Chu J Mol Endocrinol. 2008 Aug;41(2):65-74. Epub 2008 May 21. ( 1st author )

Down regulation of IGF-I and IGF-IR gene expression in right atria tissue of ventricular septal defect infants with right atria hypoxemia. Mu-Hsin Chang, Wei-Wen Kuo , Ping-Chun Li , Ding-Yu Lin , Shin-Da Lee , Fuu-Jen Tsai ,Gwo-Ping Jong , Yueh-Min Lin , Chih-Yang Huang , Wen-Jun Wu Clinica Chimica Acta: 379: 81-81, 2007.

Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts. Shin-Da Lee, Wei-Wen Kuo, James A. Lin , Yu-Fang Chu , Chin-Kun Wang , Yu-Lan Yeh, Shyi-Gang P. Wang, Jer-Yuh Liu , Mu-Hsin Chang , Chih-Yang Huang International Journal of Cardiology 116:348–356, 2007.

Serum MMP-9 Activity as a Diagnosing Marker for the Developing Heart Failure of Post MI Patients. Gwo-Ping Jong, Tsochiang Ma, Pesus Chou , Mu-Hsin Chang, Chieh-His Wu, Ping-Chun Li, Shin-Da Lee, Jer-Yuh Liu, Wei-Wen Kuo, and Chih-Yang Huang, Chinese Journal of Physiology 49(2): 104-109, 2006 .